The principal cytochrome P450 isoenzyme associated seems for being CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Roughly 85% of an oral dose appears from the urine within 24 hrs of administration, most because the glucuronide conjugate, with compact amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information.Abuse of